Mongersen (Synonyms: GED-0301)

Cat. No.: HY-145721: FAQs
Data Sheet SDS Handling Instructions

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Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Mongersen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d(P-thio)(G-T-m5C-G-C-C-C-C-T-T-C-T-C-C-C-m5C-G-C-A-G-C)

Mongersen Chemical Structure

CAS No. : 1443994-46-4

Size	Price	Stock
1 mg	USD 54	Ask For Quote & Lead Time
5 mg	USD 140	Ask For Quote & Lead Time
10 mg	USD 192	Ask For Quote & Lead Time
25 mg	USD 461	Ask For Quote & Lead Time
50 mg	USD 738	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Mongersen:

Mongersen sodium Get quote
Mongersen triethylamine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old female BALB/c mice were treated with TNBS^[2]
Dosage:	125 μg/mouse
Administration:	Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result:	Reduced Smad7 protein expression. Attenuated the ongoing colonic inflammation. Significantly reduced TNF-α and IL-6 RNA expression. Attenuated colonic fibrosis.

Clinical Trial

Molecular Weight

6584.00

CAS No.

1443994-46-4

Appearance

Solid

Color

White to off-white

SMILES

[Mongersen]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (3.04 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.1519 mL	0.7594 mL	1.5188 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Data Sheet (272 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13. [Content Brief]

[2]. Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O

1 mM

0.1519 mL

0.7594 mL

1.5188 mL

3.7971 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Mongersen Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mongersen1443994-46-4GED-0301GED0301GED 0301TGF-beta/SmadTransforming growth factor betaoralSMAD7 antisense oligonucleotideTGF-β1Crohn's diseaseInhibitorinhibitorinhibit

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