2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Apoptosis Cytoskeleton
  3. Microtubule/Tubulin ADC Cytotoxin Apoptosis
  4. Monomethyl auristatin E

Monomethyl auristatin E  (Synonyms: MMAE; SGD-1010; Vedotin)

Cat. No.: HY-15162G
Handling Instructions

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Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor.

For research use only. We do not sell to patients.

Monomethyl auristatin E Chemical Structure

Monomethyl auristatin E Chemical Structure

CAS No. : 474645-27-7

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Based on 1 publication(s) in Google Scholar

Monomethyl auristatin E Related Antibodies

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Description

Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor[1].

Molecular Weight

717.98

Formula

C39H67N5O7
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)[C@H](NC)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (69.64 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3928 mL 6.9640 mL 13.9280 mL
5 mM 0.2786 mL 1.3928 mL 2.7856 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.3928 mL 6.9640 mL 13.9280 mL 34.8199 mL
5 mM 0.2786 mL 1.3928 mL 2.7856 mL 6.9640 mL
10 mM 0.1393 mL 0.6964 mL 1.3928 mL 3.4820 mL
15 mM 0.0929 mL 0.4643 mL 0.9285 mL 2.3213 mL
20 mM 0.0696 mL 0.3482 mL 0.6964 mL 1.7410 mL
25 mM 0.0557 mL 0.2786 mL 0.5571 mL 1.3928 mL
30 mM 0.0464 mL 0.2321 mL 0.4643 mL 1.1607 mL
40 mM 0.0348 mL 0.1741 mL 0.3482 mL 0.8705 mL
50 mM 0.0279 mL 0.1393 mL 0.2786 mL 0.6964 mL
60 mM 0.0232 mL 0.1161 mL 0.2321 mL 0.5803 mL
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Monomethyl auristatin E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monomethyl auristatin E (GMP)474645-27-7MMAE (GMP) SGD-1010 (GMP) Vedotin (GMP)Microtubule/TubulinADC CytotoxinApoptosisADC PayloadGMPADCauxiliary reagentMMAEcancerInhibitorinhibitorinhibit

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