2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MP-Ala-Ala-PAB

MP-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MP-Ala-Ala-PAB Chemical Structure

MP-Ala-Ala-PAB Chemical Structure

CAS No. : 1949793-47-8

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MP-Ala-Ala-PAB Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

View All Isoforms
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MP-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MP-Ala-Ala-PAB Related Antibodies
Molecular Weight

416.43

Formula

C20H24N4O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C)NC(CCN2C(C=CC2=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 350 mg/mL (840.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4014 mL 12.0068 mL 24.0136 mL
5 mM 0.4803 mL 2.4014 mL 4.8027 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4014 mL 12.0068 mL 24.0136 mL 60.0341 mL
5 mM 0.4803 mL 2.4014 mL 4.8027 mL 12.0068 mL
10 mM 0.2401 mL 1.2007 mL 2.4014 mL 6.0034 mL
15 mM 0.1601 mL 0.8005 mL 1.6009 mL 4.0023 mL
20 mM 0.1201 mL 0.6003 mL 1.2007 mL 3.0017 mL
25 mM 0.0961 mL 0.4803 mL 0.9605 mL 2.4014 mL
30 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0011 mL
40 mM 0.0600 mL 0.3002 mL 0.6003 mL 1.5009 mL
50 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
60 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0006 mL
80 mM 0.0300 mL 0.1501 mL 0.3002 mL 0.7504 mL
100 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6003 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MP-Ala-Ala-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MP-Ala-Ala-PAB1949793-47-8ADC LinkerAntibody-drug conjugates linkerADC linkercleavableInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MP-Ala-Ala-PAB
Cat. No.:
HY-148463
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.