2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. MPP+-d3 iodide

MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

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MPP+-d<sub>3</sub> iodide Chemical Structure

MPP+-d3 iodide Chemical Structure

CAS No. : 207556-07-8

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Other Forms of MPP+-d3 iodide:

MPP+-d3 iodide Related Antibodies

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Description

MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPP+-d3 iodide Related Antibodies
Molecular Weight

300.15

Formula

C12H9D3IN
CAS No.
Unlabeled CAS

36913-39-0
Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C([2H])([2H])[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (333.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (333.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3317 mL 16.6583 mL 33.3167 mL
5 mM 0.6663 mL 3.3317 mL 6.6633 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.3317 mL 16.6583 mL 33.3167 mL 83.2917 mL
5 mM 0.6663 mL 3.3317 mL 6.6633 mL 16.6583 mL
10 mM 0.3332 mL 1.6658 mL 3.3317 mL 8.3292 mL
15 mM 0.2221 mL 1.1106 mL 2.2211 mL 5.5528 mL
20 mM 0.1666 mL 0.8329 mL 1.6658 mL 4.1646 mL
25 mM 0.1333 mL 0.6663 mL 1.3327 mL 3.3317 mL
30 mM 0.1111 mL 0.5553 mL 1.1106 mL 2.7764 mL
40 mM 0.0833 mL 0.4165 mL 0.8329 mL 2.0823 mL
50 mM 0.0666 mL 0.3332 mL 0.6663 mL 1.6658 mL
60 mM 0.0555 mL 0.2776 mL 0.5553 mL 1.3882 mL
80 mM 0.0416 mL 0.2082 mL 0.4165 mL 1.0411 mL
100 mM 0.0333 mL 0.1666 mL 0.3332 mL 0.8329 mL
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MPP+-d3 iodide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPP+-d3207556-07-8Mitochondrial MetabolismInhibitorinhibitorinhibit

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