2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. MPT0B002

MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase.

For research use only. We do not sell to patients.

MPT0B002 Chemical Structure

MPT0B002 Chemical Structure

CAS No. : 946077-08-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

MPT0B002 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase[1].

In Vitro

MPT0B002 (1-1000 nM; 48 h) induces G2/M-phase cell cycle arrest[1].
MPT0B002 (100 nM; 24 h) inhibits cell viability in a dose-dependent manner in K562, BaF3/p210, and BaF3/T315I cells[1].
MPT0B002 (100 nM; 48 h) induces apoptosis and can downregulate both Bcr-Abl and Bcr-Abl-T315I mRNA expressions and protein levels and the downstream signaling pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPT0B002 Related Antibodies

Cell Viability Assay[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 1 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 48 h
Result: Inhibited cell viability in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Induced G2/M-phase cell cycle arrest.

Apoptosis Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Induced apoptosis and caspase-3 pathway.

Western Blot Analysis[1]

Cell Line: K562, BaF3/p210, and BaF3/T315I cells
Concentration: 100 nM
Incubation Time: 48 h
Result: Significantly reduced the expression level of Bcr-Abl, and reduced the phosphorylations of Crkl and Stat5.
Molecular Weight

325.36

Formula

C19H19NO4
CAS No.
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=CC3=C(C=C2)N(C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MPT0B002 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPT0B002946077-08-3Microtubule/TubulinApoptosismicrotubule inhibitoranticancer activitiestubulin polymerizationinduces apoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MPT0B002
Cat. No.:
HY-122151
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.