2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. MRE-269-d7

MRE-269-d7  (Synonyms: ACT-333679-d7)

Cat. No.: HY-79593S2 Purity: 99.59%
COA Handling Instructions

Molarity Calculator

MRE-269-d7 is deuterium labeled MRE-269 (HY-79593). MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist[1][2].

For research use only. We do not sell to patients.

MRE-269-d<sub>7</sub> Chemical Structure

MRE-269-d7 Chemical Structure

CAS No. : 1265295-20-2

Size Price Stock Quantity
1 mg USD 550 In-stock
5 mg USD 1600 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MRE-269-d7:

MRE-269-d7 Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MRE-269-d7 is deuterium labeled MRE-269 (HY-79593). MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRE-269-d7 Related Antibodies
Molecular Weight

426.56

Formula

C25H22D7N3O3
CAS No.
Unlabeled CAS

475085-57-5
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(COCCCCN(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (117.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (117.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3443 mL 11.7217 mL 23.4434 mL
5 mM 0.4689 mL 2.3443 mL 4.6887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.3443 mL 11.7217 mL 23.4434 mL 58.6084 mL
5 mM 0.4689 mL 2.3443 mL 4.6887 mL 11.7217 mL
10 mM 0.2344 mL 1.1722 mL 2.3443 mL 5.8608 mL
15 mM 0.1563 mL 0.7814 mL 1.5629 mL 3.9072 mL
20 mM 0.1172 mL 0.5861 mL 1.1722 mL 2.9304 mL
25 mM 0.0938 mL 0.4689 mL 0.9377 mL 2.3443 mL
30 mM 0.0781 mL 0.3907 mL 0.7814 mL 1.9536 mL
40 mM 0.0586 mL 0.2930 mL 0.5861 mL 1.4652 mL
50 mM 0.0469 mL 0.2344 mL 0.4689 mL 1.1722 mL
60 mM 0.0391 mL 0.1954 mL 0.3907 mL 0.9768 mL
80 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7326 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.5861 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MRE-269-d7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRE-269-d71265295-20-2ACT-333679-d7Prostaglandin ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MRE-269-d7
Cat. No.:
HY-79593S2
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.