2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. MRGPRX4 modulator-2

MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions.

For research use only. We do not sell to patients.

MRGPRX4 modulator-2 Chemical Structure

MRGPRX4 modulator-2 Chemical Structure

CAS No. : 2492595-24-9

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 850 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

MRGPRX4 modulator-2 Related Antibodies

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Description

MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions[1].

IC50 & Target

IC50: < 100 nM (MRGPR X4)[1]
Molecular Weight

348.68

Formula

C15H9ClF4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=CC(COC2=CC=C(C(F)(F)F)C=C2Cl)=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8680 mL 14.3398 mL 28.6796 mL
5 mM 0.5736 mL 2.8680 mL 5.7359 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8680 mL 14.3398 mL 28.6796 mL 71.6990 mL
5 mM 0.5736 mL 2.8680 mL 5.7359 mL 14.3398 mL
10 mM 0.2868 mL 1.4340 mL 2.8680 mL 7.1699 mL
15 mM 0.1912 mL 0.9560 mL 1.9120 mL 4.7799 mL
20 mM 0.1434 mL 0.7170 mL 1.4340 mL 3.5849 mL
25 mM 0.1147 mL 0.5736 mL 1.1472 mL 2.8680 mL
30 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3900 mL
40 mM 0.0717 mL 0.3585 mL 0.7170 mL 1.7925 mL
50 mM 0.0574 mL 0.2868 mL 0.5736 mL 1.4340 mL
60 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL
80 mM 0.0358 mL 0.1792 mL 0.3585 mL 0.8962 mL
100 mM 0.0287 mL 0.1434 mL 0.2868 mL 0.7170 mL
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MRGPRX4 modulator-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRGPRX4 modulator-22492595-24-9Mas-related G-protein-coupled Receptor (MRGPR)MRGPRMRGPR X4Autoimmunepsoriasismultiple sclerosisSteven Johnson’s Syndrome,Inhibitorinhibitorinhibit

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