MRS2179 tetrasodium hydrate

Name: MRS2179 tetrasodium hydrate
Brand: MedChemExpress
SKU: HY-101308A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101308A Purity: 99.6%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium hydrate inhibits platelet aggregation.

For research use only. We do not sell to patients.

MRS2179 tetrasodium hydrate Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MRS2179 tetrasodium hydrate:

MRS2179 tetrasodium Get quote
MRS-2179 Get quote

1 Publications Citing Use of MCE MRS2179 tetrasodium hydrate

•Mil Med Res. 2024 Jun 27;11(1):41. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors^[1]^[2]. MRS2179 tetrasodium hydrate inhibits platelet aggregation^[3].

In Vivo

MRS2179 tetrasodium hydrate (50 mg/kg; i.p.) prolongs the bleeding time^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CL57BLr6 mice^[3]
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

Molecular Weight

576.21

Formula

C₁₁H₁₃N₅O₉P₂Na₄.3?H₂O

Appearance

Solid

Color

White to off-white

SMILES

CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1.O.[3.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 28.81 mg/mL (50.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7355 mL	8.6774 mL	17.3548 mL
5 mM	0.3471 mL	1.7355 mL	3.4710 mL
10 mM	0.1735 mL	0.8677 mL	1.7355 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.6%

Select Batch:

Data Sheet (282 KB) SDS (252 KB)

COA (261 KB) Elemental Analysis Report (120 KB)

Handling Instructions (2659 KB)

References

[1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]

[2]. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432. [Content Brief]

[3]. Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7355 mL	8.6774 mL	17.3548 mL	43.3870 mL
	5 mM	0.3471 mL	1.7355 mL	3.4710 mL	8.6774 mL
	10 mM	0.1735 mL	0.8677 mL	1.7355 mL	4.3387 mL
	15 mM	0.1157 mL	0.5785 mL	1.1570 mL	2.8925 mL
	20 mM	0.0868 mL	0.4339 mL	0.8677 mL	2.1693 mL
	25 mM	0.0694 mL	0.3471 mL	0.6942 mL	1.7355 mL
	30 mM	0.0578 mL	0.2892 mL	0.5785 mL	1.4462 mL
	40 mM	0.0434 mL	0.2169 mL	0.4339 mL	1.0847 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.