MRS2179 tetrasodium

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MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors. MRS2179 tetrasodium inhibits platelet aggregation.

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MRS2179 tetrasodium Chemical Structure

CAS No. : 1454889-37-2

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Other Forms of MRS2179 tetrasodium:

MRS2179 tetrasodium hydrate Get quote
MRS-2179 Get quote

1 Publications Citing Use of MCE MRS2179 tetrasodium

•Mil Med Res. 2024 Jun 27;11(1):41. [Abstract]

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

Biological Activity
Purity & Documentation
References
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Description

MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors^[1]^[2]. MRS2179 tetrasodium inhibits platelet aggregation^[3].

IC₅₀ & Target

P2Y1 Receptor

In Vivo

MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CL57BLr6 mice^[3]
Dosage:	50 mg/kg
Administration:	Injection into the jugular vein of mice
Result:	The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.

Molecular Weight

513.16

Formula

C₁₁H₁₃N₅Na₄O₉P₂

CAS No.

1454889-37-2

SMILES

CNC1=C2C(N([C@](C[C@@H]3O[P](O[Na])(O[Na])=O)([H])O[C@@H]3CO[P](O[Na])(O[Na])=O)C=N2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842. [Content Brief]

[2]. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110(3):415-432. [Content Brief]

[3]. Baurand A, Raboisson P, Freund M, et al. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol. 2001;412(3):213-221. [Content Brief]