MRS4596

Cat. No.: HY-151546: FAQs
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MRS4596 is a potent and selective P2X4 receptor antagonist with an IC₅₀ value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .

For research use only. We do not sell to patients.

MRS4596 Chemical Structure

CAS No. : 2840581-38-4

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC₅₀: 1.38 μM (human P2X4 receptor)^[1]

In Vivo

MRS4719 (compound 22c; 5 mg/kg; 3 days continuous infusion with an Alzet minipump) has neuroprotective and learning- and memory-enhancing activities in a mouse middle cerebral artery occlusion (MCAO) model of ischemic stroke^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)^[1]
Dosage:	5 mg/kg
Administration:	3 days continuous infusion with an Alzet minipump
Result:	Decreased in total hemispheric infarct volume while effects were not significant on cortical or striatal infarct volume alone.

Molecular Weight

438.43

Formula

C₂₂H₁₅N₄NaO₃S

CAS No.

2840581-38-4

SMILES

O=C(C1)NC(C2=CC=C(C=C2C=C3)C)=C3N(C4=CC=CC(C([N-]5)=NOC5=S)=C4)C1=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Toti KS, et al. Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-diones as P2X4 Receptor Antagonists. J Med Chem. 2022 Sep 23. [Content Brief]

MRS4596 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS45962840581-38-4MRS 4596MRS-4596P2X ReceptorP2XRsInfarctbrain atrophyneuroprotectiveischemic strokemacrophagesoldagingInhibitorinhibitorinhibit

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