2. Epigenetics Apoptosis
  3. MDM-2/p53 Histone Acetyltransferase
  4. MS78

MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker.

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MS78 Chemical Structure

MS78 Chemical Structure

CAS No. : 3034773-00-4

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1 mg USD 800 In-stock
5 mg USD 2000 In-stock
10 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

MS78 Related Antibodies

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Description

MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].

Molecular Weight

1024.25

Formula

C57H66FN9O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 135 mg/mL (131.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9763 mL 4.8816 mL 9.7632 mL
5 mM 0.1953 mL 0.9763 mL 1.9526 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9763 mL 4.8816 mL 9.7632 mL 24.4081 mL
5 mM 0.1953 mL 0.9763 mL 1.9526 mL 4.8816 mL
10 mM 0.0976 mL 0.4882 mL 0.9763 mL 2.4408 mL
15 mM 0.0651 mL 0.3254 mL 0.6509 mL 1.6272 mL
20 mM 0.0488 mL 0.2441 mL 0.4882 mL 1.2204 mL
25 mM 0.0391 mL 0.1953 mL 0.3905 mL 0.9763 mL
30 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8136 mL
40 mM 0.0244 mL 0.1220 mL 0.2441 mL 0.6102 mL
50 mM 0.0195 mL 0.0976 mL 0.1953 mL 0.4882 mL
60 mM 0.0163 mL 0.0814 mL 0.1627 mL 0.4068 mL
80 mM 0.0122 mL 0.0610 mL 0.1220 mL 0.3051 mL
100 mM 0.0098 mL 0.0488 mL 0.0976 mL 0.2441 mL
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MS78 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS783034773-00-4MS 78MS-78MDM-2/p53Histone AcetyltransferaseHATsHATp300/CBPp53Y220CTRAILDNA damageacetylationInhibitorinhibitorinhibit

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