2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. MSG606

MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MSG606 Chemical Structure

MSG606 Chemical Structure

CAS No. : 1416983-77-1

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Based on 1 publication(s) in Google Scholar

Other Forms of MSG606:

MSG606 Related Antibodies

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View All Melanocortin Receptor Isoform Specific Products:

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MC1R MC3R MC2R MC4R MC5R

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Description

MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects[1].

IC50 & Target

MC1R[1]
Molecular Weight

1347.51

Formula

C62H82N20O13S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{Bua}GH-{d-Phe}-R-{d-Trp}-CDRFG-NH2 (Carba sulfide bridge:Bua1-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (37.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7421 mL 3.7105 mL 7.4211 mL
5 mM 0.1484 mL 0.7421 mL 1.4842 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7421 mL 3.7105 mL 7.4211 mL 18.5527 mL
5 mM 0.1484 mL 0.7421 mL 1.4842 mL 3.7105 mL
10 mM 0.0742 mL 0.3711 mL 0.7421 mL 1.8553 mL
15 mM 0.0495 mL 0.2474 mL 0.4947 mL 1.2368 mL
20 mM 0.0371 mL 0.1855 mL 0.3711 mL 0.9276 mL
25 mM 0.0297 mL 0.1484 mL 0.2968 mL 0.7421 mL
30 mM 0.0247 mL 0.1237 mL 0.2474 mL 0.6184 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MSG606 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSG6061416983-77-1MSG 606MSG-606Melanocortin ReceptorMC ReceptorselectivemelanocortinneuroprotectiveMC3RInhibitorinhibitorinhibit

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