2. Epigenetics
  3. Histone Methyltransferase
  4. MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC50 of 2 nM. MU1656 can be used for the research of hematological malignancies.

For research use only. We do not sell to patients.

MU1656 Chemical Structure

MU1656 Chemical Structure

CAS No. : 2766698-38-6

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MU1656 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC50 of 2 nM. MU1656 can be used for the research of hematological malignancies[1].

IC50 & Target[1]

DOT1L

 

DOT1L

2 nM (IC50)

Molecular Weight

559.75

Formula

C32H45N7O2
CAS No.
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MU1656 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU16562766698-38-6MU 1656MU-1656Histone Methyltransferasehematological malignanciesInhibitorinhibitorinhibit

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