2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Mulberrofuran H

Mulberrofuran H is a 2-arylbenzofuran derivative from the cultivated mulberry tree (Morus lhou (ser.) Koidz.). Mulberrofuran H demonstrates potent inhibition against substrates L-tyrosine (IC50=4.45 µM) and L-DOPA (IC50=19.70 µM). Mulberrofuran H also shows potent anti-inflammatory and antioxidative activities.

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Mulberrofuran H Chemical Structure

Mulberrofuran H Chemical Structure

CAS No. : 89199-99-5

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Mulberrofuran H Related Antibodies

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Description

Mulberrofuran H is a 2-arylbenzofuran derivative from the cultivated mulberry tree (Morus lhou (ser.) Koidz.). Mulberrofuran H demonstrates potent inhibition against substrates L-tyrosine (IC50=4.45 µM) and L-DOPA (IC50=19.70 µM). Mulberrofuran H also shows potent anti-inflammatory and antioxidative activities[1][2][3].

IC50 & Target

4.45 µM (L-tyrosine); 19.70 µM (L-DOPA)[3]
Cellular Effect
Cell Line Type Value Description References
Hep 3B2 IC50
> 30 μM
Compound: 5
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
[PMID: 19072214]
Hep 3B2 IC50
140 nM
Compound: 5
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
[PMID: 19072214]
Hep 3B2 IC50
15.4 μM
Compound: 5
Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA
[PMID: 19072214]
THP-1 IC50
3.2 μM
Compound: 3
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
Molecular Weight

442.46

Formula

C27H22O6
CAS No.
SMILES

C[C@@]12CC(CC(C3=C(C=C(C4=CC5=C(C=C(O)C=C5)O4)C=C3O)O)=C2)C6=CC=C(O)C=C6O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mulberrofuran H Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mulberrofuran H89199-99-5Dopamine ReceptorInhibitorinhibitorinhibit

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