2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Mycothiazole

Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans.

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Mycothiazole Chemical Structure

Mycothiazole Chemical Structure

CAS No. : 114582-75-1

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Mycothiazole Related Antibodies

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Description

Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans[1].

Molecular Weight

404.57

Formula

C22H32N2O3S
CAS No.
SMILES

COC(NCCC(/C=C\C[C@H](O)C(C)(C1=NC(C/C=C\CC=C)=CS1)C)=C)=O
Structure Classification
Initial Source

marine sponge
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Mycothiazole Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mycothiazole114582-75-1Mitochondrial MetabolismC. eleganshepatocellular carcinomaglioblastomabreast cancerMCF7Huh7U87BJHEK293Inhibitorinhibitorinhibit

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