Mycothiazole

Cat. No.: HY-N12887: FAQs
Data Sheet Handling Instructions

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Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans.

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Mycothiazole Chemical Structure

CAS No. : 114582-75-1

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.35 nM Compound: 1	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	[PMID: 32071675]
HepG2	IC₅₀	0.27 nM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	[PMID: 32071675]
PANC-1	IC₅₀	0.16 nM Compound: 1	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	[PMID: 32071675]

Molecular Weight

404.57

Formula

C₂₂H₃₂N₂O₃S

CAS No.

114582-75-1

SMILES

COC(NCCC(/C=C\C[C@H](O)C(C)(C1=NC(C/C=C\CC=C)=CS1)C)=C)=O

Structure Classification

Others

Initial Source

marine sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dutta N,et al., Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Apr 3. [Content Brief]

Mycothiazole Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mycothiazole114582-75-1Mitochondrial MetabolismC. eleganshepatocellular carcinomaglioblastomabreast cancerMCF7Huh7U87BJHEK293Inhibitorinhibitorinhibit

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