2. Induced Disease Models Products
  3. Immunology and Inflammatory Disease Models
  4. Myocarditis Models
  5. Myosin H Chain Fragment, mouse

Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model.

For research use only. We do not sell to patients.

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Myosin H Chain Fragment, mouse Chemical Structure

Myosin H Chain Fragment, mouse Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Myosin H Chain Fragment, mouse Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Myosin H Chain Fragment, mouse

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Description

Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model[1][2].

In Vivo

Myosin H Chain Fragment, mouse can be used in animal modeling to create myocarditis models[1][3].

Induction of myocarditis[1][2]
Background
Myosin H Chain Fragment, mouse causes myocarditis by inducing cardiac inflammation, triggering an autoimmune response and increasing leukocyte infiltration.
Specific Mmodeling Methods
Mice: Balb/c • male • 6-8 weeks old
Administration: 150 μg • s.c. • days 0 and 7
Note
(1) Mice were divided into 2 groups, the control group contained 10 mice, and the Myosin H Chain Fragment, mouse induced group included 12 mice.
(2) Echocardiography was performed on days 0, 7, and 21 using an anaesthesia system under continuous 2%-3% isoflurane anaesthesia, and the temperature of the mice was adjusted to 37 ± 0.5 °C using a heating pad and rectal probe.
(3) Mice were executed 21 days after drug administration, and the hearts were immediately excised and cut along the short axis of the left ventricle at the level of the middle ventricle, then fixed overnight in 4% formaldehyde, paraffin sections were prepared and stained with hematoxylin and eosin for histopathological examination.
Modeling Indicators
Organizational changes: A marked inflammatory infiltrate was present, with a significant increase in left ventricular thickness.
Echocardiography: Decreased left ventricular systolic function and increased left ventricular internal diastolic diameter (LVIDd) and systolic internal diameter (LVID).
Correlated Product(s): /
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2073.37

Formula

C91H149N25O28S
Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp-Arg
Sequence Shortening

Ac-RSLKLMATLFSTYASADR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (8.04 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (6.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4823 mL 2.4115 mL 4.8231 mL
5 mM 0.0965 mL 0.4823 mL 0.9646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.56%

SDS (252 KB)

COA (244 KB) RP-HPLC (111 KB) MS (220 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.4823 mL 2.4115 mL 4.8231 mL 12.0577 mL
5 mM 0.0965 mL 0.4823 mL 0.9646 mL 2.4115 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Myosin H Chain Fragment, mouse Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myosin H Chain Fragment, mouseOtherspeptideα-MyosinheavychainexperimentalautoimmunemyocarditisEAMInhibitorinhibitorinhibit

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Myosin H Chain Fragment, mouse
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HY-P2464
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