N-Acetyl-L-tyrosine-d₃

Name: N-Acetyl-L-tyrosine-d 3
Brand: MedChemExpress
SKU: HY-W012382S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012382S Purity: 98.43%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Acetyl-L-tyrosine-d₃ is the deuterium labeled N-Acetyl-L-tyrosine. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

For research use only. We do not sell to patients.

N-Acetyl-L-tyrosine-d<sub>3</sub> Chemical Structure

N-Acetyl-L-tyrosine-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Acetyl-L-tyrosine-d₃:

N-Acetyl-L-tyrosine In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

226.24

Formula

C₁₁H₁₀D₃NO₄

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC(C([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (442.01 mM; Need ultrasonic)

DMSO : 100 mg/mL (442.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (442.01 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4201 mL	22.1004 mL	44.2008 mL
5 mM	0.8840 mL	4.4201 mL	8.8402 mL
10 mM	0.4420 mL	2.2100 mL	4.4201 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.43%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (1262 KB) RP-HPLC (404 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Abdenur JE, et al. Aromatic l-aminoacid decarboxylase deficiency: unusual neonatal presentation and additional findings in organic acid analysis. Mol Genet Metab. 2006 Jan;87(1):48-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO / H₂O	1 mM	4.4201 mL	22.1004 mL	44.2008 mL	110.5021 mL
	5 mM	0.8840 mL	4.4201 mL	8.8402 mL	22.1004 mL
	10 mM	0.4420 mL	2.2100 mL	4.4201 mL	11.0502 mL
	15 mM	0.2947 mL	1.4734 mL	2.9467 mL	7.3668 mL
	20 mM	0.2210 mL	1.1050 mL	2.2100 mL	5.5251 mL
	25 mM	0.1768 mL	0.8840 mL	1.7680 mL	4.4201 mL
	30 mM	0.1473 mL	0.7367 mL	1.4734 mL	3.6834 mL
	40 mM	0.1105 mL	0.5525 mL	1.1050 mL	2.7626 mL
	50 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2100 mL
	60 mM	0.0737 mL	0.3683 mL	0.7367 mL	1.8417 mL
	80 mM	0.0553 mL	0.2763 mL	0.5525 mL	1.3813 mL
	100 mM	0.0442 mL	0.2210 mL	0.4420 mL	1.1050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.