2. PROTAC
  3. PROTAC Linkers
  4. N-(Amino-PEG5)-N-bis(PEG4-acid)

N-(Amino-PEG5)-N-bis(PEG4-acid) 

Cat. No.: HY-130695 Purity: 99.52%
COA Handling Instructions

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N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids.

For research use only. We do not sell to patients.

N-(Amino-PEG5)-N-bis(PEG4-acid) Chemical Structure

N-(Amino-PEG5)-N-bis(PEG4-acid) Chemical Structure

CAS No. : 2093152-86-2

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25 mg USD 125 In-stock
50 mg USD 200 In-stock
100 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

N-(Amino-PEG5)-N-bis(PEG4-acid) Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-(Amino-PEG5)-N-bis(PEG4-acid) Related Antibodies
Molecular Weight

776.91

Formula

C34H68N2O17
CAS No.
Appearance

Liquid (Density: 1.154±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCN)CCOCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (225.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2872 mL 6.4358 mL 12.8715 mL
5 mM 0.2574 mL 1.2872 mL 2.5743 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2872 mL 6.4358 mL 12.8715 mL 32.1788 mL
5 mM 0.2574 mL 1.2872 mL 2.5743 mL 6.4358 mL
10 mM 0.1287 mL 0.6436 mL 1.2872 mL 3.2179 mL
15 mM 0.0858 mL 0.4291 mL 0.8581 mL 2.1453 mL
20 mM 0.0644 mL 0.3218 mL 0.6436 mL 1.6089 mL
25 mM 0.0515 mL 0.2574 mL 0.5149 mL 1.2872 mL
30 mM 0.0429 mL 0.2145 mL 0.4291 mL 1.0726 mL
40 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8045 mL
50 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.6436 mL
60 mM 0.0215 mL 0.1073 mL 0.2145 mL 0.5363 mL
80 mM 0.0161 mL 0.0804 mL 0.1609 mL 0.4022 mL
100 mM 0.0129 mL 0.0644 mL 0.1287 mL 0.3218 mL
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N-(Amino-PEG5)-N-bis(PEG4-acid) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(Amino-PEG5)-N-bis(PEG4-acid)2093152-86-2PROTAC LinkersPROTAClinkeraminoInhibitorinhibitorinhibit

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