N-Boc-PEG5-bromide

Name: N-Boc-PEG5-bromide
Brand: MedChemExpress
SKU: HY-120702
Rating: 4.5 (1 reviews)

Cat. No.: HY-120702 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

N-Boc-PEG5-bromide Chemical Structure

CAS No. : 1392499-32-9

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
1 g	USD 260	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cleavable Linker

PEGs

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.31

Formula

C₁₅H₃₀BrNO₆

CAS No.

1392499-32-9

Appearance

Liquid (Density: 1.223 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCBr)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 200 mg/mL (499.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4981 mL	12.4903 mL	24.9806 mL
5 mM	0.4996 mL	2.4981 mL	4.9961 mL
10 mM	0.2498 mL	1.2490 mL	2.4981 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.49 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 5 mg/mL (12.49 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (240 KB) HNMR (131 KB) MS (151 KB)

Handling Instructions (2659 KB)

References

[1]. Carston R. Wagner, et al. Protein nanorings. US8236925B1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.4981 mL	12.4903 mL	24.9806 mL	62.4516 mL
	5 mM	0.4996 mL	2.4981 mL	4.9961 mL	12.4903 mL
	10 mM	0.2498 mL	1.2490 mL	2.4981 mL	6.2452 mL
	15 mM	0.1665 mL	0.8327 mL	1.6654 mL	4.1634 mL
	20 mM	0.1249 mL	0.6245 mL	1.2490 mL	3.1226 mL
	25 mM	0.0999 mL	0.4996 mL	0.9992 mL	2.4981 mL
	30 mM	0.0833 mL	0.4163 mL	0.8327 mL	2.0817 mL
	40 mM	0.0625 mL	0.3123 mL	0.6245 mL	1.5613 mL
	50 mM	0.0500 mL	0.2498 mL	0.4996 mL	1.2490 mL
	60 mM	0.0416 mL	0.2082 mL	0.4163 mL	1.0409 mL
	80 mM	0.0312 mL	0.1561 mL	0.3123 mL	0.7806 mL
	100 mM	0.0250 mL	0.1249 mL	0.2498 mL	0.6245 mL