2. Induced Disease Models Products Cell Cycle/DNA Damage
  3. Cancer Models Urinary System Disease Models DNA Alkylator/Crosslinker
  4. Bladder Cancer Models
  5. N-Butyl-N-(4-hydroxybutyl)nitrosamine

N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents.

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N-Butyl-N-(4-hydroxybutyl)nitrosamine Chemical Structure

N-Butyl-N-(4-hydroxybutyl)nitrosamine Chemical Structure

CAS No. : 3817-11-6

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N-Butyl-N-(4-hydroxybutyl)nitrosamine Related Antibodies

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Description

N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents[1].

In Vivo

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN; 0.05% solution in drinking water; for 2 weeks) is a powerful mutagen in urothelial tissue in mice and rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female lacI C57BL/6 homozygous mice and male lacI Fisher 344 rats[1]
Dosage: 0.05% solution in drinking water
Administration: Oral; for 2 weeks
Result: The mutantfractions were extremely high in the bladder tissues.
Molecular Weight

174.24

Formula

C8H18N2O2
CAS No.
SMILES

CCCCN(N=O)CCCCO
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References
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N-Butyl-N-(4-hydroxybutyl)nitrosamine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Butyl-N-(4-hydroxybutyl)nitrosamine3817-11-6DNA Alkylator/Crosslinkerbladder cancermutagenInhibitorinhibitorinhibit

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