2. Induced Disease Models Products Cell Cycle/DNA Damage
  3. Cancer Models Urinary System Disease Models DNA Alkylator/Crosslinker
  4. Bladder Cancer Models
  5. N-Butyl-N-(4-hydroxybutyl)nitrosamine

N-Butyl-N-(4-hydroxybutyl)nitrosamine 

Cat. No.: HY-W755252 Purity: 99.68%
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N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents.

For research use only. We do not sell to patients.

N-Butyl-N-(4-hydroxybutyl)nitrosamine Chemical Structure

N-Butyl-N-(4-hydroxybutyl)nitrosamine Chemical Structure

CAS No. : 3817-11-6

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Based on 1 publication(s) in Google Scholar

N-Butyl-N-(4-hydroxybutyl)nitrosamine Related Antibodies

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Description

N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents[1].

In Vivo

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN; 0.05% solution in drinking water; for 2 weeks) is a powerful mutagen in urothelial tissue in mice and rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female lacI C57BL/6 homozygous mice and male lacI Fisher 344 rats[1]
Dosage: 0.05% solution in drinking water
Administration: Oral; for 2 weeks
Result: The mutantfractions were extremely high in the bladder tissues.
Molecular Weight

174.24

Formula

C8H18N2O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCN(N=O)CCCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1147.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7392 mL 28.6961 mL 57.3921 mL
5 mM 1.1478 mL 5.7392 mL 11.4784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

SDS (557 KB)

COA (241 KB) HNMR (254 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7392 mL 28.6961 mL 57.3921 mL 143.4803 mL
5 mM 1.1478 mL 5.7392 mL 11.4784 mL 28.6961 mL
10 mM 0.5739 mL 2.8696 mL 5.7392 mL 14.3480 mL
15 mM 0.3826 mL 1.9131 mL 3.8261 mL 9.5654 mL
20 mM 0.2870 mL 1.4348 mL 2.8696 mL 7.1740 mL
25 mM 0.2296 mL 1.1478 mL 2.2957 mL 5.7392 mL
30 mM 0.1913 mL 0.9565 mL 1.9131 mL 4.7827 mL
40 mM 0.1435 mL 0.7174 mL 1.4348 mL 3.5870 mL
50 mM 0.1148 mL 0.5739 mL 1.1478 mL 2.8696 mL
60 mM 0.0957 mL 0.4783 mL 0.9565 mL 2.3913 mL
80 mM 0.0717 mL 0.3587 mL 0.7174 mL 1.7935 mL
100 mM 0.0574 mL 0.2870 mL 0.5739 mL 1.4348 mL
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N-Butyl-N-(4-hydroxybutyl)nitrosamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Butyl-N-(4-hydroxybutyl)nitrosamine3817-11-6DNA Alkylator/Crosslinkerbladder cancermutagenInhibitorinhibitorinhibit

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