2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Anti-infection
  3. mAChR Opioid Receptor Drug Metabolite Virus Protease
  4. N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d8 hydrochloride  (Synonyms: Norclozapine-d8 hydrochloride; Desmethylclozapine-d8 hydrochloride; Normethylclozapine-d8 hydrochloride)

Cat. No.: HY-G0021S1 Purity: 99.74%
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N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

For research use only. We do not sell to patients.

N-Desmethylclozapine-d<sub>8</sub> hydrochloride Chemical Structure

N-Desmethylclozapine-d8 hydrochloride Chemical Structure

CAS No. : 2705402-91-9

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5 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-Desmethylclozapine-d8 hydrochloride:

N-Desmethylclozapine-d8 hydrochloride Related Antibodies

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Description

N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Desmethylclozapine-d8 hydrochloride Related Antibodies
Molecular Weight

357.31

Formula

C17H10D8Cl2N4
CAS No.
Unlabeled CAS

6104-71-8
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (139.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7987 mL 13.9935 mL 27.9869 mL
5 mM 0.5597 mL 2.7987 mL 5.5974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7987 mL 13.9935 mL 27.9869 mL 69.9673 mL
5 mM 0.5597 mL 2.7987 mL 5.5974 mL 13.9935 mL
10 mM 0.2799 mL 1.3993 mL 2.7987 mL 6.9967 mL
15 mM 0.1866 mL 0.9329 mL 1.8658 mL 4.6645 mL
20 mM 0.1399 mL 0.6997 mL 1.3993 mL 3.4984 mL
25 mM 0.1119 mL 0.5597 mL 1.1195 mL 2.7987 mL
30 mM 0.0933 mL 0.4664 mL 0.9329 mL 2.3322 mL
40 mM 0.0700 mL 0.3498 mL 0.6997 mL 1.7492 mL
50 mM 0.0560 mL 0.2799 mL 0.5597 mL 1.3993 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1661 mL
80 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8746 mL
100 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
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N-Desmethylclozapine-d8 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Desmethylclozapine-d82705402-91-9Norclozapine-d8Desmethylclozapine-d8Normethylclozapine-d8mAChROpioid ReceptorDrug MetaboliteVirus ProteaseMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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