2. Induced Disease Models Products Cell Cycle/DNA Damage
  3. Cancer Models DNA/RNA Synthesis
  4. Leukemia Models
  5. N-Ethyl-N-nitrosourea

N-Ethyl-N-nitrosourea  (Synonyms: ENU; N-Nitroso-N-ethylurea)

Cat. No.: HY-W019815 Purity: 99.85%
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N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders.

For research use only. We do not sell to patients.

N-Ethyl-N-nitrosourea Chemical Structure

N-Ethyl-N-nitrosourea Chemical Structure

CAS No. : 759-73-9

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N-Ethyl-N-nitrosourea Related Antibodies

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Description

N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2].

Molecular Weight

117.11

Formula

C3H7N3O2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=NN(CC)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 350 mg/mL (2988.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.5390 mL 42.6949 mL 85.3898 mL
5 mM 1.7078 mL 8.5390 mL 17.0780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.5390 mL 42.6949 mL 85.3898 mL 213.4745 mL
5 mM 1.7078 mL 8.5390 mL 17.0780 mL 42.6949 mL
10 mM 0.8539 mL 4.2695 mL 8.5390 mL 21.3475 mL
15 mM 0.5693 mL 2.8463 mL 5.6927 mL 14.2316 mL
20 mM 0.4269 mL 2.1347 mL 4.2695 mL 10.6737 mL
25 mM 0.3416 mL 1.7078 mL 3.4156 mL 8.5390 mL
30 mM 0.2846 mL 1.4232 mL 2.8463 mL 7.1158 mL
40 mM 0.2135 mL 1.0674 mL 2.1347 mL 5.3369 mL
50 mM 0.1708 mL 0.8539 mL 1.7078 mL 4.2695 mL
60 mM 0.1423 mL 0.7116 mL 1.4232 mL 3.5579 mL
80 mM 0.1067 mL 0.5337 mL 1.0674 mL 2.6684 mL
100 mM 0.0854 mL 0.4269 mL 0.8539 mL 2.1347 mL
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N-Ethyl-N-nitrosourea Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Ethyl-N-nitrosourea759-73-9ENU N-Nitroso-N-ethylureaDNA/RNA SynthesisDNA alkylating agentleukemiateratogenicratsCNSInhibitorinhibitorinhibit

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