N-Isobutyrylglycine-d₂

Name: N-Isobutyrylglycine-d 2
Brand: MedChemExpress
SKU: HY-W141928S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-W141928S1 Purity: 99.43%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Isobutyrylglycine-d₂ is the deuterium labeled N-Isobutyrylglycine[1].

For research use only. We do not sell to patients.

N-Isobutyrylglycine-d<sub>2</sub> Chemical Structure

N-Isobutyrylglycine-d₂ Chemical Structure

CAS No. : 1219795-05-7

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of N-Isobutyrylglycine-d₂:

N-Isobutyrylglycine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Isobutyrylglycine-d₂ is the deuterium labeled N-Isobutyrylglycine[1].

Cellular Effect

Cell Line	Type	Value	Description	References
KB 3-1	IC₅₀	> 20 mM Compound: 9	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	> 20 mM Compound: 9	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

147.17

Formula

C₆H₉D₂NO₃

CAS No.

1219795-05-7

Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])NC(C(C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (135.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7949 mL	33.9743 mL	67.9486 mL
5 mM	1.3590 mL	6.7949 mL	13.5897 mL
10 mM	0.6795 mL	3.3974 mL	6.7949 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.43%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (246 KB) HNMR (484 KB) RP-HPLC (627 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.7949 mL	33.9743 mL	67.9486 mL	169.8716 mL
	5 mM	1.3590 mL	6.7949 mL	13.5897 mL	33.9743 mL
	10 mM	0.6795 mL	3.3974 mL	6.7949 mL	16.9872 mL
	15 mM	0.4530 mL	2.2650 mL	4.5299 mL	11.3248 mL
	20 mM	0.3397 mL	1.6987 mL	3.3974 mL	8.4936 mL
	25 mM	0.2718 mL	1.3590 mL	2.7179 mL	6.7949 mL
	30 mM	0.2265 mL	1.1325 mL	2.2650 mL	5.6624 mL
	40 mM	0.1699 mL	0.8494 mL	1.6987 mL	4.2468 mL
	50 mM	0.1359 mL	0.6795 mL	1.3590 mL	3.3974 mL
	60 mM	0.1132 mL	0.5662 mL	1.1325 mL	2.8312 mL
	80 mM	0.0849 mL	0.4247 mL	0.8494 mL	2.1234 mL
	100 mM	0.0679 mL	0.3397 mL	0.6795 mL	1.6987 mL