2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-methyl-N-dithiocarboxyglucamine sodium

N-methyl-N-dithiocarboxyglucamine sodium  (Synonyms: MDCG sodium)

Cat. No.: HY-111054A Purity: 98.60%
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N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity.

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N-methyl-N-dithiocarboxyglucamine sodium Chemical Structure

N-methyl-N-dithiocarboxyglucamine sodium Chemical Structure

CAS No. : 91840-27-6

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10 mg USD 100 In-stock
25 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-methyl-N-dithiocarboxyglucamine sodium:

N-methyl-N-dithiocarboxyglucamine sodium Related Antibodies

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Description

N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity[1].

In Vivo

N-methyl-N-dithiocarboxyglucamine (1.1 mM/kg; ip; single dose) could significantly induce the excretion of Cd from feces. Increasing the number of treatments to 7 times per week, N-methyl-N-dithiocarboxyglucamine results in a more than 50% reduction in systemic Cd load in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

293.34

Formula

C8H16NNaO5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CN(C)C(S[Na])=S
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (213.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4090 mL 17.0451 mL 34.0901 mL
5 mM 0.6818 mL 3.4090 mL 6.8180 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4090 mL 17.0451 mL 34.0901 mL 85.2253 mL
5 mM 0.6818 mL 3.4090 mL 6.8180 mL 17.0451 mL
10 mM 0.3409 mL 1.7045 mL 3.4090 mL 8.5225 mL
15 mM 0.2273 mL 1.1363 mL 2.2727 mL 5.6817 mL
20 mM 0.1705 mL 0.8523 mL 1.7045 mL 4.2613 mL
25 mM 0.1364 mL 0.6818 mL 1.3636 mL 3.4090 mL
30 mM 0.1136 mL 0.5682 mL 1.1363 mL 2.8408 mL
40 mM 0.0852 mL 0.4261 mL 0.8523 mL 2.1306 mL
50 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7045 mL
60 mM 0.0568 mL 0.2841 mL 0.5682 mL 1.4204 mL
80 mM 0.0426 mL 0.2131 mL 0.4261 mL 1.0653 mL
100 mM 0.0341 mL 0.1705 mL 0.3409 mL 0.8523 mL
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N-methyl-N-dithiocarboxyglucamine sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-methyl-N-dithiocarboxyglucamine91840-27-6MDCGEndogenous MetaboliteInhibitorinhibitorinhibit

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