2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. N-Nitrosodiethylamine-d10

N-Nitrosodiethylamine-d10  (Synonyms: Diethylnitrosamine-d10; DEN-d10)

Cat. No.: HY-N7434S1 Purity: 99.68%
COA Handling Instructions

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N-Nitrosodiethylamine-d10 is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

For research use only. We do not sell to patients.

N-Nitrosodiethylamine-d<sub>10</sub> Chemical Structure

N-Nitrosodiethylamine-d10 Chemical Structure

CAS No. : 1219794-54-3

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1 mg USD 75 In-stock
5 mg USD 190 In-stock
10 mg USD 310 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-Nitrosodiethylamine-d10:

N-Nitrosodiethylamine-d10 Related Antibodies

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Description

N-Nitrosodiethylamine-d10 is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Nitrosodiethylamine-d10 Related Antibodies
Molecular Weight

112.20

Formula

C4D10N2O
CAS No.
Unlabeled CAS

55-18-5
Appearance

Liquid

Color

Light yellow to yellow

SMILES

[2H]C([2H])([2H])C([2H])([2H])N(N=O)C([2H])([2H])C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (891.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (891.27 mM; Need ultrasonic)

H2O : 100 mg/mL (891.27 mM; Need ultrasonic)

DMSO : 100 mg/mL (891.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.9127 mL 44.5633 mL 89.1266 mL
5 mM 1.7825 mL 8.9127 mL 17.8253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / H2O / DMSO 1 mM 8.9127 mL 44.5633 mL 89.1266 mL 222.8164 mL
5 mM 1.7825 mL 8.9127 mL 17.8253 mL 44.5633 mL
10 mM 0.8913 mL 4.4563 mL 8.9127 mL 22.2816 mL
15 mM 0.5942 mL 2.9709 mL 5.9418 mL 14.8544 mL
20 mM 0.4456 mL 2.2282 mL 4.4563 mL 11.1408 mL
25 mM 0.3565 mL 1.7825 mL 3.5651 mL 8.9127 mL
30 mM 0.2971 mL 1.4854 mL 2.9709 mL 7.4272 mL
40 mM 0.2228 mL 1.1141 mL 2.2282 mL 5.5704 mL
50 mM 0.1783 mL 0.8913 mL 1.7825 mL 4.4563 mL
60 mM 0.1485 mL 0.7427 mL 1.4854 mL 3.7136 mL
80 mM 0.1114 mL 0.5570 mL 1.1141 mL 2.7852 mL
100 mM 0.0891 mL 0.4456 mL 0.8913 mL 2.2282 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Nitrosodiethylamine-d10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nitrosodiethylamine-d101219794-54-3Diethylnitrosamine-d10 DEN-d10DNA/RNA SynthesisInhibitorinhibitorinhibit

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