N2-Methyl-L-arginine

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N2-Methyl-L-arginine is a selective L-arginine uptake inhibitor, with a K_i value of 500 μM.

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N2-Methyl-L-arginine Chemical Structure

Size	Stock	Quantity
5 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

N2-Methyl-L-arginine is a selective L-arginine uptake inhibitor, with a K_i value of 500 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Macrophage	IC₅₀	28 μM Compound: L-NMMA	Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages by Griess reagent method Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages by Griess reagent method	[PMID: 12542351]
Macrophage	IC₅₀	64.24 μM Compound: L-NMMA	Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control	[PMID: 18723353]
Peritoneal macrophage cell	IC₅₀	36 μM Compound: L-NMMA	Hepatoprotective activity in ddY mouse peritoneal macrophages assessed as inhibition of LPS-induced nitric oxide production after 20 hrs by Griess method relative to untreated control Hepatoprotective activity in ddY mouse peritoneal macrophages assessed as inhibition of LPS-induced nitric oxide production after 20 hrs by Griess method relative to untreated control	[PMID: 19775895]
RAW264.7	IC₅₀	39.2 μM Compound: N-monomethyl-L-arginine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay	[PMID: 24547740]
Sf9	IC₅₀	0.65 μM Compound: L-NMMA	Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting	[PMID: 22420844]
Sf9	IC₅₀	0.95 μM Compound: L-NMMA	Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting	[PMID: 22420844]
Sf9	IC₅₀	1.8 μM Compound: L-NMMA	Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubated for 15 mins with compound measured after 45 mins by scintillation counting	[PMID: 22420844]

Molecular Weight

188.23

Formula

C₇H₁₆N₄O₂

CAS No.

2480-28-6

SMILES

N=C(N)NCCC[C@@H](C(O)=O)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pisoni RL, et al. Important differences in cationic amino acid transport by lysosomal system c and system y+ of the human fibroblast. J Biol Chem. 1987 Nov 5;262(31):15011-8. [Content Brief]