N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

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N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).

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N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine Chemical Structure

CAS No. : 2305416-07-1

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Description	N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)^[1].
Molecular Weight	366.37
Formula	C₁₅H₂₂N₆O₅
CAS No.	2305416-07-1
SMILES	O=C1N(C)C(/N=C/N(C)C)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief] [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. [Content Brief]