2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. NAQ

NAQ is a potent and selective μ opioid receptor partial agonist, with a Ki of 0.55 nM. NAQ shows selectivity for Mu opioid receptor over the δ receptor (Ki=132.50 nM) and the κ receptor (Ki=26.45 nM). NAQ can be used for the research of opioid withdrawal or dependence.

For research use only. We do not sell to patients.

NAQ Chemical Structure

NAQ Chemical Structure

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NAQ Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

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Description

NAQ is a potent and selective μ opioid receptor partial agonist, with a Ki of 0.55 nM. NAQ shows selectivity for Mu opioid receptor over the δ receptor (Ki=132.50 nM) and the κ receptor (Ki=26.45 nM). NAQ can be used for the research of opioid withdrawal or dependence[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

0.55 nM (Ki)

κ Opioid Receptor/KOR

26.45 nM (Ki)

δ Opioid Receptor/DOR

132.50 nM (Ki)

In Vitro

NAQ is a μ opioid receptor (MOR) partial agonist, with an EC50 of 4.36 nM in MOR-expressing CHO cell line[1].
NAQ (45 min) inhibits hERG with an IC50 of 220 nM in CHO-K1 cells stably transfected with human hERG cDNA[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAQ Related Antibodies
In Vivo

NAQ (a single s.c.) antagonizes the antinociceptive effects of Morphine in the mouse tail immersion test, with an AD50 of 0.45 mg/kg[1].
NAQ (0.32-10 mg/kg; s.c.) produces weak intracranial self-stimulation (ICSS) facilitation in rats but more robust ICSS facilitation during and after Morphine treatment and also reverses Morphine withdrawal-associated depression of ICSS[2].

Pharmacokinetics of NAQ in rats[3]

t1/2
(min)		 Vss
(L/kg)		 CL(mL/min/kg) AUCInf
(h⋅ng/mL)		 Tmax
(min)		 Cmax
(ng/mL)		 F
(%)
1 mg/kg IV 32.4 3.0 86 202 / / /
10 mg/kg PO / / / 114 36 20 3

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

497.58

Formula

C30H31N3O4
SMILES

O=C(C1=CC2=C(C=N1)C=CC=C2)N[C@H]3[C@@H]4[C@]56C7=C(O4)C(O)=CC=C7C[C@@H](N(CC8CC8)CC6)[C@@]5(O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NAQ Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAQOpioid ReceptorInhibitorinhibitorinhibit

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