2. Inhibitory Antibodies
  3. Narnatumab

Narnatumab  (Synonyms: IMC-RON8; LY3012219; Anti-MSPR/RON/CD136 Reference Antibody (narnatumab))

Cat. No.: HY-P99375

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Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No. : 1188275-92-4

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Description

Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

RON(MSPR)[1]
In Vitro

Narnatumab (100 nM; 24 h) inhibits MSP-induced migration of human lung and breast cancer cell lines[1].
Narnatumab inhibits the MSP-induced mitogenic response of a pancreatic cancer cell line[1].
Narnatumab (0.01-100 nM; pretreatment for 1 h) blocks ligand-induced receptor phosphorylation and downstream signaling molecules phosphorylation in RON-expressing tumor cells and in a RON-transfected cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Narnatumab Related Antibodies
In Vivo

Narnatumab (2-60 mg/kg; i.p. every 3 days) shows antitumor activity in non-small cell lung cancer (NSCLC) and bladder cancer models in athymic mice[1].
Narnatumab exhibits terminal half-life (t1/2=5.2 d) and achieves antitumor effects at a steady-state plasma trough level of approximately 140 μg/mL in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nu/nu mice (6-8 weeks) were injected NCI-H292 and BFTC-905 cells[1]
Dosage: 2, 20, 60 mg/kg
Administration: I.p. every 3 days for 36 and 18 days
Result: Inhibited tumor growth in a dose-dependent manner.
CAS No.
SMILES

[Narnatumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Narnatumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Narnatumab1188275-92-4IMC-RON8 LY3012219 Anti-MSPR/RON/CD136 Reference Antibody (narnatumab)LY3012219LY 3012219LY-3012219OthersRONmacrophage-stimulating proteinMSPcancerInhibitorinhibitorinhibit

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