NBD-125

Cat. No.: HY-133739: FAQs
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NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell.

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NBD-125 Chemical Structure

CAS No. : 2367641-24-3

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RXRα RXRβ RXRγ

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Description

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	27.17 μM Compound: B-12	Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay	[PMID: 32391701]
KM12C	IC₅₀	31.1 μM Compound: B-12	Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay	[PMID: 32391701]
SW-620	IC₅₀	36.19 μM Compound: B-12	Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay	[PMID: 32391701]

In Vitro

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth^[1].
NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Km12c, HCT116 and SW620 cell lines.
Concentration:	0-50 μM, 0-60, 0-80 μM.
Incubation Time:	15 h.
Result:	Downregulated c-Myc, Cdc42 protein levels.

Molecular Weight

327.80

Formula

C₁₉H₁₈ClNO₂

CAS No.

2367641-24-3

SMILES

COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855. [Content Brief]

NBD-125 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBD-1252367641-24-3NBD125NBD 125RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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