2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. FLT3 IRAK
  4. NCGC1481

NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity.

For research use only. We do not sell to patients.

NCGC1481 Chemical Structure

NCGC1481 Chemical Structure

CAS No. : 2193085-94-6

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NCGC1481 Related Antibodies

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Description

NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity[1].

Molecular Weight

389.45

Formula

C21H23N7O
CAS No.
SMILES

CN1N=CC(C2=CN3C(C=C2OC)=NC=C3C4=CC=CC(NC5CNCC5)=N4)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NCGC1481 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCGC14812193085-94-6NCGC 1481NCGC-1481FLT3IRAKCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Interleukin-1 receptor associated kinaseIL-1R associated kinaseFLT3-ITD AMLLeukemia modelInhibitorinhibitorinhibit

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