NCL1

Cat. No.: HY-12645: FAQs
Data Sheet Handling Instructions Technical Support

NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC₅₀ values of 2.5 and 26 μM for LSD1 and LSD2, respectively.

For research use only. We do not sell to patients.

NCL1 Chemical Structure

CAS No. : 1196119-03-5

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Histone Demethylase Isoform Specific Products:

View All Isoforms

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

LSD1

2.5 ± 0.5 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 32931269]
HCT-116	GI₅₀	6 μM Compound: 31	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22975593]
HeLa	GI₅₀	13 μM Compound: 4; NCL1	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
HeLa	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 32931269]
HeLa	GI₅₀	6 μM Compound: 31	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 22975593]
KYSE-150 cell line	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay	[PMID: 32931269]
KYSE-150 cell line	GI₅₀	6 μM Compound: 31	Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay	[PMID: 22975593]
PC-3	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay	[PMID: 32931269]
PC-3	GI₅₀	6 μM Compound: 31	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 22975593]
SH-SY5Y	GI₅₀	27 μM Compound: 4; NCL1	Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
SH-SY5Y	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 32931269]
SH-SY5Y	GI₅₀	6 μM Compound: 31	Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 22975593]

Molecular Weight

443.54

Formula

C₂₇H₂₉N₃O₃

CAS No.

1196119-03-5

SMILES

O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kakizawa T, et al. Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1193-5. [Content Brief]

NCL1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCL11196119-03-5NCL 1NCL-1Histone DemethylaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

NCL1

NCL1 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Histone Demethylase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

NCL1 Related Classifications

Molarity Calculator

Dilution Calculator