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  4. Neocarzilin A

Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1.

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Neocarzilin A Chemical Structure

Neocarzilin A Chemical Structure

CAS No. : 124958-29-8

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Description

Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1[1][2].

Molecular Weight

323.64

Formula

C14H17Cl3O2
CAS No.
Appearance

Oil

Color

Light yellow to orange

SMILES

CC[C@H](C)/C=C/C=C/C=C/C(O)=C/C(C(Cl)(Cl)Cl)=O
Structure Classification
Initial Source

Streptomyces carzinostaticus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (308.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0899 mL 15.4493 mL 30.8985 mL
5 mM 0.6180 mL 3.0899 mL 6.1797 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0899 mL 15.4493 mL 30.8985 mL 77.2463 mL
5 mM 0.6180 mL 3.0899 mL 6.1797 mL 15.4493 mL
10 mM 0.3090 mL 1.5449 mL 3.0899 mL 7.7246 mL
15 mM 0.2060 mL 1.0300 mL 2.0599 mL 5.1498 mL
20 mM 0.1545 mL 0.7725 mL 1.5449 mL 3.8623 mL
25 mM 0.1236 mL 0.6180 mL 1.2359 mL 3.0899 mL
30 mM 0.1030 mL 0.5150 mL 1.0300 mL 2.5749 mL
40 mM 0.0772 mL 0.3862 mL 0.7725 mL 1.9312 mL
50 mM 0.0618 mL 0.3090 mL 0.6180 mL 1.5449 mL
60 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2874 mL
80 mM 0.0386 mL 0.1931 mL 0.3862 mL 0.9656 mL
100 mM 0.0309 mL 0.1545 mL 0.3090 mL 0.7725 mL
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Neocarzilin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neocarzilin A124958-29-8NCAOthersantimigratoryantiproliferativeMDA-MB-231HeLaInhibitorinhibitorinhibit

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