2. Natural Products
  3. Plants Flavonoids
  4. Leguminosae Other Flavonoids
  5. Erythrina sigmoidea Hua
  6. Neocyclomorusin

Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM.

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Neocyclomorusin Chemical Structure

Neocyclomorusin Chemical Structure

CAS No. : 62596-35-4

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Neocyclomorusin Related Antibodies

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Description

Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
146.1 μM
Compound: 7
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
RAW264.7 IC50
6.3 μg/mL
Compound: 5
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay
[PMID: 27908762]
Molecular Weight

436.45

Formula

C25H24O7
CAS No.
SMILES

O=C1C(C(OC(C(C(O2)=C3)=CC=C3O)=C1CC2C(C)(O)C)=C(C=CC4(C)C)C(O4)=C5)=C5O
Structure Classification
Initial Source
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neocyclomorusin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neocyclomorusin62596-35-4OthersNatural Products,FlavonoidInhibitorinhibitorinhibit

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