2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. Neuropeptide Y (18-36) (porcine)

Neuropeptide Y (18-36) (porcine) 

Cat. No.: HY-P3678 Purity: 98.76%
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Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.

For research use only. We do not sell to patients.

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Neuropeptide Y (18-36) (porcine) Chemical Structure

Neuropeptide Y (18-36) (porcine) Chemical Structure

CAS No. : 114495-97-5

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5 mg USD 275 In-stock
10 mg USD 415 In-stock
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Based on 1 publication(s) in Google Scholar

Neuropeptide Y (18-36) (porcine) Related Antibodies

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

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Description

Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].

IC50 & Target

IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]
In Vitro

Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1].
Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1].
Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide Y (18-36) (porcine) Related Antibodies
Molecular Weight

2456.80

Formula

C112H174N36O27
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

ARYYSALRHYINLITRQRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (40.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4070 mL 2.0352 mL 4.0703 mL
5 mM 0.0814 mL 0.4070 mL 0.8141 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4070 mL 2.0352 mL 4.0703 mL 10.1758 mL
5 mM 0.0814 mL 0.4070 mL 0.8141 mL 2.0352 mL
10 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0176 mL
15 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6784 mL
20 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5088 mL
25 mM 0.0163 mL 0.0814 mL 0.1628 mL 0.4070 mL
30 mM 0.0136 mL 0.0678 mL 0.1357 mL 0.3392 mL
40 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2544 mL
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Neuropeptide Y (18-36) (porcine) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide Y (18-36) (porcine)114495-97-5Neuropeptide Y ReceptorNPY receptorcompetitiveneuropeptide Y (NPY)cardiac receptorantagonistI-NPYrat cardiac ventricular membranescongestive heart failureInhibitorinhibitorinhibit

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