2. NF-κB
  3. NF-κB
  4. NF-κB-IN-15

NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI).

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NF-κB-IN-15 Chemical Structure

NF-κB-IN-15 Chemical Structure

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NF-κB-IN-15 Related Antibodies

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Description

NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI)[1].

In Vitro

NF-κB-IN-15 (compound 14r) (1.25, 2.5, 5, 10, 20 µM; 1+24 h) decreases the NO levels in a dose-dependent manner and inhibits the release of IL-6, TNF-α, and IL-1β in LPS-induced RAW 264.7 cells[1].
NF-κB-IN-15 (10, 20 µM; 1+4 h) inhibits LPS-induced phosphorylation of p65 and degradation of IκBα[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-15 Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW 264.7 cells[1]
Concentration: 10, 20 µM
Incubation Time: 1 h (LPS (1 μg/mL) for 4 h)
Result: Decreased the expression of p-p65and inhibited degradation of IκBα. LPS-induced levels of IL-6, TNF-α, and IL-1β.
In Vivo

NF-κB-IN-15 (compound 14r) (20 mg/kg; i.p.) shows anti-inflammatory activity in Acute lung injury (ALI) mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20 g, Male C57BL/6 mice[1]
Dosage: 20 mg/kg+LPS (15 mg/kg, i. p.)
Administration: I.p.
Result: Reduced the LPS-induced levels of IL-6, TNF-α, and IL-1β in the bronchoalveolar lavage fluid (BALF) and acute lung injury.
Molecular Weight

794.97

Formula

C46H58N4O8
SMILES

CC1=C(C)C=CC=C1N2CCN(C([C@H](CC3=CC(OC)=C(O)C(OC)=C3)[C@@H](C(N4CCN(C5=CC=CC(C)=C5C)CC4)=O)CC6=CC(OC)=C(O)C(OC)=C6)=O)CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NF-κB-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-15NF-κBNuclear factor-κBNuclear factor-kappaBRAW 264.7 cellsLPSp-p65IκBαIL-6TNF-αIL-1βanti-inflammatoryInhibitorinhibitorinhibit

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