NH2-PEG1-C1-Boc

Cat. No.: HY-W073709: FAQs
Data Sheet Handling Instructions

Molarity Calculator

NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG1-C1-Boc Chemical Structure

CAS No. : 1155811-37-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

175.23

Formula

C₈H₁₇NO₃

CAS No.

1155811-37-2

SMILES

O=C(OC(C)(C)C)COCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (142.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7068 mL	28.5339 mL	57.0679 mL
5 mM	1.1414 mL	5.7068 mL	11.4136 mL
10 mM	0.5707 mL	2.8534 mL	5.7068 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.7068 mL	28.5339 mL	57.0679 mL	142.6696 mL
	5 mM	1.1414 mL	5.7068 mL	11.4136 mL	28.5339 mL
	10 mM	0.5707 mL	2.8534 mL	5.7068 mL	14.2670 mL
	15 mM	0.3805 mL	1.9023 mL	3.8045 mL	9.5113 mL
	20 mM	0.2853 mL	1.4267 mL	2.8534 mL	7.1335 mL
	25 mM	0.2283 mL	1.1414 mL	2.2827 mL	5.7068 mL
	30 mM	0.1902 mL	0.9511 mL	1.9023 mL	4.7557 mL
	40 mM	0.1427 mL	0.7133 mL	1.4267 mL	3.5667 mL
	50 mM	0.1141 mL	0.5707 mL	1.1414 mL	2.8534 mL
	60 mM	0.0951 mL	0.4756 mL	0.9511 mL	2.3778 mL
	80 mM	0.0713 mL	0.3567 mL	0.7133 mL	1.7834 mL
	100 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.4267 mL

NH2-PEG1-C1-Boc Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG1-C1-Boc1155811-37-2PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks