2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. NH2-PEG4-DOTA

NH2-PEG4-DOTA is a bifunctional, DOTA-type metal chelator. NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex. NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.

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NH2-PEG4-DOTA Chemical Structure

NH2-PEG4-DOTA Chemical Structure

CAS No. : 2090232-34-9

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NH2-PEG4-DOTA Related Antibodies

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Description

NH2-PEG4-DOTA is a bifunctional, DOTA-type metal chelator. NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex. NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.

IC50 & Target

RDC Bifunctional Chelator

 

Molecular Weight

622.71

Formula

C26H50N6O11
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NCCOCCOCCOCCOCCN)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6059 mL 8.0294 mL 16.0588 mL
5 mM 0.3212 mL 1.6059 mL 3.2118 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6059 mL 8.0294 mL 16.0588 mL 40.1471 mL
5 mM 0.3212 mL 1.6059 mL 3.2118 mL 8.0294 mL
10 mM 0.1606 mL 0.8029 mL 1.6059 mL 4.0147 mL
15 mM 0.1071 mL 0.5353 mL 1.0706 mL 2.6765 mL
20 mM 0.0803 mL 0.4015 mL 0.8029 mL 2.0074 mL
25 mM 0.0642 mL 0.3212 mL 0.6424 mL 1.6059 mL
30 mM 0.0535 mL 0.2676 mL 0.5353 mL 1.3382 mL
40 mM 0.0401 mL 0.2007 mL 0.4015 mL 1.0037 mL
50 mM 0.0321 mL 0.1606 mL 0.3212 mL 0.8029 mL
60 mM 0.0268 mL 0.1338 mL 0.2676 mL 0.6691 mL
80 mM 0.0201 mL 0.1004 mL 0.2007 mL 0.5018 mL
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NH2-PEG4-DOTA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG4-DOTA2090232-34-9Radionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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