2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Niraxostat

Niraxostat  (Synonyms: Y-700; Piraxostat)

Cat. No.: HY-14669 Purity: 98.54%
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Niraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved.

For research use only. We do not sell to patients.

Niraxostat Chemical Structure

Niraxostat Chemical Structure

CAS No. : 206884-98-2

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1 mg USD 345 In-stock
5 mg USD 710 In-stock
10 mg USD 1040 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Niraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved[1].

In Vivo

Niraxostat (Y-700; 1 mg/kg) has high oral bioavailability (84.1%) and is almost not excreted through the kidneys. It is mainly eliminated through the liver[1].
Niraxostat (Y- 700; 1-10 mg/kg; oral; single dose) dose-dependently reduces plasma urate levels in oxonate-treated rats [1].
Niraxostat (Y-700 ; 0.3-3 mg/kg; Oral; Single dose) In normal rats, dose-dependently reduces urinary excretion of urate and allantoin while increasing excretion of hypoxanthine and xanthine [1].

Pharmacokinetic Analysis of Niraxostat (Y-700) in normal rats[1]

Route Dose (mg/kg) tmax (h) Cmax (μg/ml) AUC0-∞ (μg/h/ml) t1/2 (h)
PO 0.3 0.5 0.43 2.07 5.0
PO 1 0.3 1.8 7.01 3.2
PO 3 0.5 6.49 30.31 2.7
IV 1 / 3.97 8.34 2.5

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

299.32

Formula

C16H17N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2=CC=C(OCC(C)(C)C)C(C#N)=C2)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (278.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3409 mL 16.7045 mL 33.4091 mL
5 mM 0.6682 mL 3.3409 mL 6.6818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3409 mL 16.7045 mL 33.4091 mL 83.5226 mL
5 mM 0.6682 mL 3.3409 mL 6.6818 mL 16.7045 mL
10 mM 0.3341 mL 1.6705 mL 3.3409 mL 8.3523 mL
15 mM 0.2227 mL 1.1136 mL 2.2273 mL 5.5682 mL
20 mM 0.1670 mL 0.8352 mL 1.6705 mL 4.1761 mL
25 mM 0.1336 mL 0.6682 mL 1.3364 mL 3.3409 mL
30 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7841 mL
40 mM 0.0835 mL 0.4176 mL 0.8352 mL 2.0881 mL
50 mM 0.0668 mL 0.3341 mL 0.6682 mL 1.6705 mL
60 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
80 mM 0.0418 mL 0.2088 mL 0.4176 mL 1.0440 mL
100 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niraxostat206884-98-2Y-700 PiraxostatY700Y 700Xanthine OxidaseXOInhibitorinhibitorinhibit

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