2. Anti-infection
  3. RSV
  4. Nirsevimab

Nirsevimab  (Synonyms: MEDI8897)

Cat. No.: HY-P99756 Purity: ≥95.0%
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Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections.

For research use only. We do not sell to patients.

CAS No. : 1989556-22-0

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Nirsevimab Related Antibodies

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Description

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections[1][2].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

IC50: 5.42 ng/mL, 9.71 ng/mL (RSV A, RSV B)[1].
In Vitro

Nirsevimab can directly neutralize RSV virus and has fragment crystallizable (Fc) - mediated effector function, thereby preventing respiratory infections[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nirsevimab Related Antibodies
In Vivo

Nirsevimab (10-10000 μg/kg; i.m.) inhibits the antibody response in the respiratory mucosa of mice when pre-administered prior to RSV virus infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-week-old female BALB/c mice[2].
Dosage: 10 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Intramuscular injection (i.m.); administer medication 24 hours prior to RSV virus exposure
Result: Inhibited the secretion of sIgA, mucosal IgA, and mucosal IgG in the offspring subsequent to the initial RSV infection.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Nirsevimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Nirsevimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nirsevimab1989556-22-0MEDI8897MEDI 8897MEDI-8897RSVRespiratory syncytial virusantibodyrespiratory tract infectionInhibitorinhibitorinhibit

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