2. Membrane Transporter/Ion Channel Neuronal Signaling Autophagy
  3. Calcium Channel Autophagy
  4. Nitrendipine-d5

Nitrendipine-d5  (Synonyms: AY-E-5009-d5)

Cat. No.: HY-B0424S Purity: 99.76%
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Nitrendipine-d5 is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect[1][2][3][4].

For research use only. We do not sell to patients.

Nitrendipine-d<sub>5</sub> Chemical Structure

Nitrendipine-d5 Chemical Structure

CAS No. : 2469554-26-3

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100 μg USD 80 In-stock
1 mg USD 320 In-stock
5 mg USD 620 In-stock
10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nitrendipine-d5:

Nitrendipine-d5 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Nitrendipine-d5 is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nitrendipine-d5 Related Antibodies
Molecular Weight

365.39

Formula

C18H15D5N2O6
CAS No.
Unlabeled CAS

39562-70-4
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C1=C(C)NC(C)=C(C1C2=CC([N+]([O-])=O)=CC=C2)C(OC([2H])([2H])C([2H])([2H])[2H])=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (342.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7368 mL 13.6840 mL 27.3680 mL
5 mM 0.5474 mL 2.7368 mL 5.4736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7368 mL 13.6840 mL 27.3680 mL 68.4200 mL
5 mM 0.5474 mL 2.7368 mL 5.4736 mL 13.6840 mL
10 mM 0.2737 mL 1.3684 mL 2.7368 mL 6.8420 mL
15 mM 0.1825 mL 0.9123 mL 1.8245 mL 4.5613 mL
20 mM 0.1368 mL 0.6842 mL 1.3684 mL 3.4210 mL
25 mM 0.1095 mL 0.5474 mL 1.0947 mL 2.7368 mL
30 mM 0.0912 mL 0.4561 mL 0.9123 mL 2.2807 mL
40 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7105 mL
50 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3684 mL
60 mM 0.0456 mL 0.2281 mL 0.4561 mL 1.1403 mL
80 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8553 mL
100 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6842 mL
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Nitrendipine-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrendipine-d52469554-26-3AY-E-5009-d5Calcium ChannelAutophagyCa2+ channelsCa channelsInhibitorinhibitorinhibit

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