2. Immunology/Inflammation
  3. Interleukin Related NOD-like Receptor (NLR)
  4. NLRP3-IN-25

NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM.

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NLRP3-IN-25 Chemical Structure

NLRP3-IN-25 Chemical Structure

CAS No. : 2660230-90-8

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5 mg USD 165 In-stock
10 mg USD 265 In-stock
25 mg USD 530 In-stock
50 mg USD 850 In-stock
100 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

NLRP3-IN-25 Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

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Description

NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].

Molecular Weight

448.42

Formula

C17H19F3N4O5S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=COC(NC2=CC(C(F)(F)F)=CC=C2C)=N1)NS(=O)(N3CCOCCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (390.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2301 mL 11.1503 mL 22.3005 mL
5 mM 0.4460 mL 2.2301 mL 4.4601 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2301 mL 11.1503 mL 22.3005 mL 55.7513 mL
5 mM 0.4460 mL 2.2301 mL 4.4601 mL 11.1503 mL
10 mM 0.2230 mL 1.1150 mL 2.2301 mL 5.5751 mL
15 mM 0.1487 mL 0.7434 mL 1.4867 mL 3.7168 mL
20 mM 0.1115 mL 0.5575 mL 1.1150 mL 2.7876 mL
25 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2301 mL
30 mM 0.0743 mL 0.3717 mL 0.7434 mL 1.8584 mL
40 mM 0.0558 mL 0.2788 mL 0.5575 mL 1.3938 mL
50 mM 0.0446 mL 0.2230 mL 0.4460 mL 1.1150 mL
60 mM 0.0372 mL 0.1858 mL 0.3717 mL 0.9292 mL
80 mM 0.0279 mL 0.1394 mL 0.2788 mL 0.6969 mL
100 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5575 mL
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NLRP3-IN-25 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-252660230-90-8Interleukin RelatedNOD-like Receptor (NLR)ILorally activeanti-inflammatory activityInhibitorinhibitorinhibit

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