2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-46

NLRP3-IN-46 (Compound 3k) activates neuro-immunomodulatory cholinergic anti-inflammatory pathway, and thus inhibits NLRP3 inflammasome activation. NLRP3-IN-46 inhibits Uric acid sodium (HY-B2130A)-induced IL-1β production in THP-1 cells, and can be used in gouty arthritis research.

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NLRP3-IN-46 Chemical Structure

NLRP3-IN-46 Chemical Structure

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NLRP3-IN-46 Related Antibodies

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Description

NLRP3-IN-46 (Compound 3k) activates neuro-immunomodulatory cholinergic anti-inflammatory pathway, and thus inhibits NLRP3 inflammasome activation. NLRP3-IN-46 inhibits Uric acid sodium (HY-B2130A)-induced IL-1β production in THP-1 cells, and can be used in gouty arthritis research[1].

Molecular Weight

425.36

Formula

C23H25BrN2O
SMILES

BrC1=CC=CC=C1OC2=NC(C[C@H]3[C@](C=C)([H])[C@]4(N(C)C)CC(C)=C3)=C4C=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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NLRP3-IN-46 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-46NOD-like Receptor (NLR)gouty arthritisTHP-1Inhibitorinhibitorinhibit

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