NLRP3-IN-NBC6

Cat. No.: HY-131040 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC₅₀= 574 nM) that acts independently of Ca²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

For research use only. We do not sell to patients.

NLRP3-IN-NBC6 Chemical Structure

CAS No. : 2068818-02-8

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

NLRP3

574 nM (IC₅₀)

In Vitro

In LPS-primed primary BMDMs, NLRP3-IN-NBC6 (10 μM; 15 minutes) inhibits Imiquimod-induced IL-1β release. NLRP3-IN-NBC6 completely inhibits NLRP3-dependent IL-1β release in neutrophils (neutrophils were isolated from WT and NLRP3 KO murine bone marrow and primed with LPS followed by Nigericin treatment in the presence of 10 μM NLRP3-IN-NBC6)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.50

Formula

C₁₈H₁₆BCl₃N₂O₂

CAS No.

2068818-02-8

Appearance

Solid

Color

White to off-white

SMILES

CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.40%

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Data Sheet (277 KB) SDS (251 KB)

COA (261 KB) Elemental Analysis Report (120 KB)

Handling Instructions (2659 KB)

References

[1]. Baldwin AG, et al. Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem Biol. 2017;24(11):1321-1335.e5. [Content Brief]

NLRP3-IN-NBC6 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-NBC62068818-02-8NOD-like Receptor (NLR)selectiveinflammasomeneutrophilsbonemarrow-derivedmacrophagesLPSInhibitorinhibitorinhibit

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