NLS-StAx-h

Cat. No.: HY-P2272: FAQs
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NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells.

For research use only. We do not sell to patients.

NLS-StAx-h Chemical Structure

CAS No. : 2872559-21-0

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100 μg		Get quote	Estimated Time of Arrival: December 31

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Description

IC₅₀ & Target

IC₅₀: 1.4 μM (Wnt)^[1]

In Vitro

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells^[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	SW-480 and DLD-1 cells
Concentration:	10 μM
Incubation Time:	72 hr
Result:	Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay ^[1]

Cell Line:	DLD-1 cells
Concentration:	5 and 10 μM
Incubation Time:	24 hr
Result:	Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).

Molecular Weight

3445.25

Formula

C₁₆₁H₂₇₅N₅₅O₂₉

CAS No.

2872559-21-0

SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCNC(N)=N)C(N[C@@]2(C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C)(CCC/C=C/CCC2)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](CCCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(N)=N)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)CC(O)=O)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)C)=O)=O)[C@@H](NC([C@H](CCCCNC(N)=N)NC([C@H](CCCCNC(N)=N)NC(COCCOCCNC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H]6CCCN6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions [Content Brief]

[2]. ang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41(4):2109-2129. [Content Brief]

NLS-StAx-h Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLS-StAx-h2872559-21-0Wntβ-cateninBeta cateninstapledpeptideproliferationmigrationcolorectalcancerInhibitorinhibitorinhibit

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