2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. NLS-StAx-h TFA

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NLS-StAx-h TFA Chemical Structure

NLS-StAx-h TFA Chemical Structure

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100 μg USD 400 In-stock
500 μg USD 800 In-stock
1 mg USD 1050 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NLS-StAx-h TFA:

NLS-StAx-h TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NLS-StAx-h TFA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells[1][2].

IC50 & Target

IC50: 1.4 μM (Wnt)[1]
In Vitro

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NLS-StAx-h TFA Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SW-480 and DLD-1 cells
Concentration: 10 μM
Incubation Time: 72 hr
Result: Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay [1]

Cell Line: DLD-1 cells
Concentration: 5 and 10 μM
Incubation Time: 24 hr
Result: Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).
Molecular Weight

3559.28

Formula

C162H276F3N55O31
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (28.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2810 mL 1.4048 mL 2.8096 mL
5 mM 0.0562 mL 0.2810 mL 0.5619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2810 mL 1.4048 mL 2.8096 mL 7.0239 mL
5 mM 0.0562 mL 0.2810 mL 0.5619 mL 1.4048 mL
10 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7024 mL
15 mM 0.0187 mL 0.0937 mL 0.1873 mL 0.4683 mL
20 mM 0.0140 mL 0.0702 mL 0.1405 mL 0.3512 mL
25 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2810 mL
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NLS-StAx-h TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLS-StAx-hWntβ-cateninBeta cateninanti-proliferationSW-480DLD-1Inhibitorinhibitorinhibit

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