2. Anti-infection
  3. HIV Reverse Transcriptase
  4. NNRT-IN-2

NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics.

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NNRT-IN-2 Chemical Structure

NNRT-IN-2 Chemical Structure

CAS No. : 2999794-78-2

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NNRT-IN-2 Related Antibodies

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Description

NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics[1].

IC50 & Target

EC50: 22 nM (HIV Reverse Transcriptase)[1]
Molecular Weight

417.34

Formula

C19H14F3N5O3
CAS No.
SMILES

CN1C(NN=C1CN2C=CC(C(F)(F)F)=C(C2=O)OC3=C4C=CN=CC4=CC=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NNRT-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNRT-IN-22999794-78-2HIVReverse TranscriptaseHuman immunodeficiency virusATDPHIV-1NNRTIsPyridoneRTInhibitorinhibitorinhibit

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