2. Anti-infection Membrane Transporter/Ion Channel
  3. HIV Potassium Channel Reverse Transcriptase
  4. NNRT-IN-4

NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM). NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg).

For research use only. We do not sell to patients.

NNRT-IN-4 Chemical Structure

NNRT-IN-4 Chemical Structure

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NNRT-IN-4 Related Antibodies

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Description

NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM). NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg)[1].

Molecular Weight

618.72

Formula

C36H38N6O4
SMILES

CC1=C(OC2=C(C(OCC)=O)C=NC(NC3CCN(CC4=CC=C(C(NC)=O)C=C4)CC3)=N2)C(C)=CC(C5=CC=C(C#N)C=C5)=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NNRT-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNRT-IN-4HIVPotassium ChannelReverse TranscriptaseHuman immunodeficiency virusKcsAL100IK103NY181CY188LE138KMT-4Inhibitorinhibitorinhibit

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