Nocistatin(human)

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Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E₂.

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Nocistatin(human) Chemical Structure

CAS No. : 212609-11-5

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Description	Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E₂^[1].
In Vitro	Nocistatin (5.0 nmol) significantly improves the nociception (5.0 nmol)-induced impairment of learning and memory without changing motor activity or response to electric shocks^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Nocistatin(human) Related Antibodies
Molecular Weight	3561.93
Formula	C₁₄₉H₂₃₈N₄₂O₅₃S₃
CAS No.	212609-11-5
Sequence	Met-Pro-Arg-Val-Arg-Ser-Leu-Phe-Gln-Glu-Gln-Glu-Glu-Pro-Glu-Pro-Gly-Met-Glu-Glu-Ala-Gly-Glu-Met-Glu-Gln-Lys-Gln-Leu-Gln
Sequence Shortening	MPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. E Okuda-Ashitaka, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. [Content Brief] [2]. M Hiramatsu, et al. Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice. Eur J Pharmacol. 1999 Feb 19;367(2-3):151-5. [Content Brief]

Nocistatin(human) Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nocistatin(human)212609-11-5OthersInhibitorinhibitorinhibit

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