NOD2 antagonist 1

Cat. No.: HY-147506 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs.

For research use only. We do not sell to patients.

NOD2 antagonist 1 Chemical Structure

CAS No. : 2411441-54-6

Size	Price	Stock	Quantity
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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NLRP3 NLRP1 NOD1 NOD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

NOD2

5.23 μM (IC₅₀)

Molecular Weight

474.57

Formula

C₂₆H₂₆N₄O₃S

CAS No.

2411441-54-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC2=C(CCC2)C=C1)CN3C4=CC=CC=C4N=C3CCNS(=O)(C5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 35.71 mg/mL (75.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1072 mL	10.5359 mL	21.0717 mL
5 mM	0.4214 mL	2.1072 mL	4.2143 mL
10 mM	0.2107 mL	1.0536 mL	2.1072 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (258 KB) HNMR (143 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1072 mL	10.5359 mL	21.0717 mL	52.6793 mL
	5 mM	0.4214 mL	2.1072 mL	4.2143 mL	10.5359 mL
	10 mM	0.2107 mL	1.0536 mL	2.1072 mL	5.2679 mL
	15 mM	0.1405 mL	0.7024 mL	1.4048 mL	3.5120 mL
	20 mM	0.1054 mL	0.5268 mL	1.0536 mL	2.6340 mL
	25 mM	0.0843 mL	0.4214 mL	0.8429 mL	2.1072 mL
	30 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7560 mL
	40 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3170 mL
	50 mM	0.0421 mL	0.2107 mL	0.4214 mL	1.0536 mL
	60 mM	0.0351 mL	0.1756 mL	0.3512 mL	0.8780 mL